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Ozempic is the brand name for the medication semaglutide, which is a prescription drug used to treat type 2 diabetes. Semaglutide belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists.

GLP-1 receptor agonists work by mimicking the actions of GLP-1, a hormone that regulates blood sugar levels. By activating GLP-1 receptors, semaglutide helps to lower blood sugar levels in people with type 2 diabetes.

Ozempic is typically administered once a week as an injection under the skin (subcutaneous injection). It helps to improve glycemic control by stimulating insulin release, reducing the production of glucose by the liver, and slowing down the emptying of the stomach.

In addition to its blood sugar-lowering effects, Ozempic may also lead to weight loss in some individuals. It is often prescribed in combination with diet and exercise to manage blood sugar levels in adults with type 2 diabetes.

As with any medication, Ozempic may have potential side effects. Common side effects can include nausea, vomiting, diarrhea, decreased appetite, and abdominal pain. It is important to discuss any concerns or potential side effects with a healthcare provider before starting Ozempic or any other medication.

It's worth noting that this information is a general overview of Ozempic, and it's always important to follow the specific instructions and advice provided by a healthcare professional when taking any medication.

Which of the following components of an infection prevention bundle has the most significant impact in reducing surgical site infections in elective colorectal surgery patients?

A. Preoperative shower with 4% chlorhexidine gluconate
B. Mechanical bowel preparation
C. Intraoperative abdominal irrigation with antibiotic
D. Mechanical bowel preparation combined with oral
antibiotics
E. Dedicated instruments for wound closure

ANSWER: D

Surgical site infections (SSIs) after colorectal surgery are a significant cause of morbidity and mortality and remain an important national quality indicator. Mechanical bowel preparation plus oral antibiotics was a mainstay in colorectal
surgery for decades, but several publications questioned the efficacy of mechanical bowel preparation. Numerous randomized controlled trials failed to show any decrease in SSIs or anastomotic leak. A major criticism of these trials was
omission of the oral antibiotic portion of the standard bowel preparation. The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) retrospectively evaluated 4999 patients who underwent
colectomy.

Patients who had a combined mechanical bowel preparation and oral antibiotics had a lower 30-day rate of superficial SSIs, anastomotic leak, and 30-day readmission,
compared with mechanical bowel preparation alone. Infection prevention bundles are used to reduce the rates of infection related to central line insertions and mechanical ventilation. Several interventions in the preoperative and

perioperative arenas are proposed to reduce the rates of SSI in colorectal patients, and institutions have grouped them together in an infection prevention bundle. One group studied
the impact of each component of the infection prevention bundles: mechanical bowel preparation plus oral antibiotics, preoperative chlorhexidine shower, preoperative hair
clipping, skin preparation with a standard chlorhexidine alcohol solution, intraoperative antibiotic irrigation, and a clean closure protocol with dedicated instruments.
Multivariate analysis showed that the mechanical bowel preparation with oral antibiotics had the greatest effect on
reducing SSIs.

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